Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors.

@article{Ma2004StructureOR,
  title={Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors.},
  author={Jichun Ma and Masato Yoshimura and Eiki Yamashita and Atsushi Nakagawa and Akio Ito and Tomitake Tsukihara},
  journal={Journal of molecular biology},
  year={2004},
  volume={338 1},
  pages={103-14}
}
Monoamine oxidase (MAO), a mitochondrial outer membrane enzyme, catalyzes the degradation of neurotransmitters in the central nervous system and is the target for anti-depression drug design. Two subtypes of MAO, MAOA and MAOB, are similar in primary sequences but have unique substrate and inhibitor specificities. The structures of human MAOB complexed with various inhibitors were reported early. To understand the mechanisms of specific substrate and inhibitor recognitions of MAOA and MAOB, we… CONTINUE READING