Structure of pestalotan, a highly branched (1----3)-beta-D-glucan elaborated by Pestalotia sp. 815, and the enhancement of its antitumor activity by polyol modification of the side chains.

@article{Misaki1984StructureOP,
  title={Structure of pestalotan, a highly branched (1----3)-beta-D-glucan elaborated by Pestalotia sp. 815, and the enhancement of its antitumor activity by polyol modification of the side chains.},
  author={Akira Misaki and Kazuo Kawaguchi and Hideki Miyaji and Hideki Nagae and Satoshi Hokkoku and Mariko Kakuta and T. Sasaki},
  journal={Carbohydrate research},
  year={1984},
  volume={129},
  pages={
          209-27
        }
}
Pestalotia sp. 815, a newly isolated fungus, produces extracellularly a highly (1----6)-branched (1----3)-beta-D-glucan in high yield when grown in a D-glucose-containing medium. This extracellular glucan, designated "Pestalotan", has [alpha]25D-0.1 degree (c 0.5, M NaOH) and a molecular weight greater than 2 X 10(6). Chemical and enzymic studies indicated that pestalotan has a very highly branched structure containing a back-bone chain of beta-D-(1----3)-linked D-glucosyl residues, and three… 
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References

SHOWING 1-10 OF 10 REFERENCES
Studies on interrelation of structure and antitumor effects of polysaccharides: Antitumor action of periodate-modified, branched (1 → 3)-β-d-glucan of auricularia auricula-judae, and other polysaccharides containing (1 → 3)-glycosidic linkages☆
Antitumor activities of two (1 goes to 3)-beta-D-glucans, isolated from the fruiting body of Auricularia auricula-judae ("kikurage", an edible mushroom), and other branched polysaccharides containing
Dependence on chain length of antitumor activity of (1 leads to 3)-beta-D-glucan from Alcaligenes faecalis var. myxogenes, IFO 13140, and its acid-degraded products.
TLDR
The results from the bioassay study of the low-molecular-weight (1 leads to 3)-beta-D-glucans prepared from the glucan with number-average degrees of polymerization (DPn) 540 by hydrolysis with formic acid or sulfuric acid showed that the glucans with DPn greater than 50 inhibited the growth of Sarcoma 180 implanted s.c. in mice.
Ultrasonic degradation of schizophyllan, an antitumor polysaccharide produced by Schizophyllum commune Fries.
TLDR
End-group analysis by using radioisotope-labeled glucans suggests that ultrasonic degradation occurs mainly by cleavage of glycosidic bonds of the main chain of schizophyllan, and there is no anomalous linkage sensitive to periodate oxidation.
Further study of the structure of lentinan, an anti-tumor polysaccharide from Lentinus edodes.
TLDR
The structure of lentinan, an anti-tumor polysaccharide from Lentinus edodes, has been further investigated and it is shown that a branched molecule having a backbone of (1→3)-β-d-glucan and side chains of both β-d-(1→ 3)- and β- d-( 1→6)-linked d- glucose residues is present.
Pullulan, ein extracelluläres Glucan von Pullularia pullulans
The formation is described of a extracellular polysaccharide by a yeast-like fungus, morphologically identical with Aureobasidium pullulans syn. Pullularia pullulans. The polymer is formed in a yield
The triple helical structure of lentinan, a linear β-(1 → 3)-D-glucan
Probable models for the crystalline structure of lentinan, the β-(l → 3)-D-glucan of the fungus Lentinus elodes, were evaluated by X-ray fiber diffraction and theoretical conformational analysis of...
Colorimetric Method for Determination of Sugars and Related Substances
Simple sugars, oligosaccharides, polysaccharides, and their derivatives, including the methyl ethers with free or potentially free reducing groups, give an orangeyellow color w-hen treated with
A PHOTOMETRIC ADAPTATION OF THE SOMOGYI METHOD FOR THE DETERMINATION OF GLUCOSE
The reliability of the various Somogyi-Shaffer-Hartmann (1, 2) copper reagents for glucose determination in biological material has been established. Adaptation of these reagents to calorimetric use