Structure of oxalacetate acetylhydrolase, a virulence factor of the chestnut blight fungus.

@article{Chen2010StructureOO,
  title={Structure of oxalacetate acetylhydrolase, a virulence factor of the chestnut blight fungus.},
  author={Chen Chen and Qihong Sun and Buvaneswari Coimbatore Narayanan and Donald L. Nuss and Osnat Herzberg},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 34},
  pages={26685-96}
}
Oxalacetate acetylhydrolase (OAH), a member of the phosphoenolpyruvate mutase/isocitrate lyase superfamily, catalyzes the hydrolysis of oxalacetate to oxalic acid and acetate. This study shows that knock-out of the oah gene in Cryphonectria parasitica, the chestnut blight fungus, reduces the ability of the fungus to form cankers on chestnut trees, suggesting that OAH plays a key role in virulence. OAH was produced in Escherichia coli and purified, and its catalytic rates were determined… CONTINUE READING

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