Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition.

@article{Li2009StructureON,
  title={Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition.},
  author={Yili Li and Maike Hofmann and Qian Wang and Leslie Teng and Lukasz K. Chlewicki and Hanspeter Pircher and Roy A. Mariuzza},
  journal={Immunity},
  year={2009},
  volume={31 1},
  pages={35-46}
}
The cytolytic activity of natural killer (NK) cells is regulated by inhibitory receptors that detect the absence of self molecules on target cells. Structural studies of missing self recognition have focused on NK receptors that bind MHC. However, NK cells also possess inhibitory receptors specific for non-MHC ligands, notably cadherins, which are downregulated in metastatic tumors. We determined the structure of killer cell lectin-like receptor G1 (KLRG1) in complex with E-cadherin. KLRG1… CONTINUE READING