Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway

@article{Fraga2015StructureOM,
  title={Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway},
  author={Joana S Fraga and Ana Maranha and V{\'i}tor Mendes and Pedro Jos{\'e} Barbosa Pereira and Nuno Empadinhas and Sandra Macedo-Ribeiro},
  journal={Scientific Reports},
  year={2015},
  volume={5}
}
A novel four-step pathway identified recently in mycobacteria channels trehalose to glycogen synthesis and is also likely involved in the biosynthesis of two other crucial polymers: intracellular methylglucose lipopolysaccharides and exposed capsular glucan. The structures of three of the intervening enzymes - GlgB, GlgE, and TreS - were recently reported, providing the first templates for rational drug design. Here we describe the structural characterization of the fourth enzyme of the pathway… Expand
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