Structure of murine CTLA-4 and its role in modulating T cell responsiveness.

@article{Ostrov2000StructureOM,
  title={Structure of murine CTLA-4 and its role in modulating T cell responsiveness.},
  author={David A. Ostrov and Wei Shi and Jean Charles Schwartz and Steven C. Almo and Stanley G. Nathenson},
  journal={Science},
  year={2000},
  volume={290 5492},
  pages={816-9}
}
The effective regulation of T cell responses is dependent on opposing signals transmitted through two related cell-surface receptors, CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Dimerization of CTLA-4 is required for the formation of high-avidity complexes with B7 ligands and for transmission of signals that attenuate T cell activation. We determined the crystal structure of the extracellular portion of CTLA-4 to 2.0 angstrom resolution. CTLA-4 belongs to the immunoglobulin… CONTINUE READING

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