Structure of monoubiquitinated PCNA: implications for DNA polymerase switching and Okazaki fragment maturation.

@article{Zhang2012StructureOM,
  title={Structure of monoubiquitinated PCNA: implications for DNA polymerase switching and Okazaki fragment maturation.},
  author={Zhongtao Zhang and Sufang Zhang and Szu Hua Sharon Lin and Xiaoxiao Wang and Licheng Wu and Ernest Lee and Marietta Y. W. T. Lee},
  journal={Cell cycle},
  year={2012},
  volume={11 11},
  pages={2128-36}
}
Ubiquitination of proliferating cell nuclear antigen (PCNA) to ub-PCNA is essential for DNA replication across bulky template lesions caused by UV radiation and alkylating agents, as ub-PCNA orchestrates the recruitment and switching of translesion synthesis (TLS) polymerases with replication polymerases. This allows replication to proceed, leaving the DNA to be repaired subsequently. Defects in a TLS polymerase, Pol η, lead to a form of Xeroderma pigmentosum, a disease characterized by severe… CONTINUE READING
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