Structure of linkage disequilibrium and phenotypic associations in the maize genome.

@article{Remington2001StructureOL,
  title={Structure of linkage disequilibrium and phenotypic associations in the maize genome.},
  author={David Remington and Jeffry M. Thornsberry and Yoshihiro Matsuoka and Larissa M Wilson and Sherry R. Whitt and John Doebley and Stephen Kresovich and Major Goodman and Edward S. Buckler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 20},
  pages={11479-84}
}
Association studies based on linkage disequilibrium (LD) can provide high resolution for identifying genes that may contribute to phenotypic variation. We report patterns of local and genome-wide LD in 102 maize inbred lines representing much of the worldwide genetic diversity used in maize breeding, and address its implications for association studies in maize. In a survey of six genes, we found that intragenic LD generally declined rapidly with distance (r(2) < 0.1 within 1500 bp), but rates… CONTINUE READING
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