Structure of limonene synthase, a simple model for terpenoid cyclase catalysis.

@article{Hyatt2007StructureOL,
  title={Structure of limonene synthase, a simple model for terpenoid cyclase catalysis.},
  author={David Hyatt and Buhyun Youn and Yuxin Zhao and Bindu Santhamma and Robert M. Coates and Rodney B. Croteau and ChulHee Kang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 13},
  pages={
          5360-5
        }
}
The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion… CONTINUE READING
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