Structure of influenza virus haemagglutinin complexed with a neutralizing antibody

@article{Bizebard1995StructureOI,
  title={Structure of influenza virus haemagglutinin complexed with a neutralizing antibody},
  author={Thierry Bizebard and Beno{\^i}t Gigant and Pascal Rigolet and Bjarne Boie Rasmussen and Olivier Diat and Peter B{\~A}¶seckei and Steve A. Wharton and John J. Skehel and Marcel Knossow},
  journal={Nature},
  year={1995},
  volume={376},
  pages={92-94}
}
HAEMAGGLUTININ (HA) is the influenza surface glycoprotein that interacts with infectivity-neutralizing antibodies. As a consequence of this immune pressure, it is the variable virus component, which is important in antigenic drift, that results in recurrent epidemics of influenza. We have determined the crystallographic structure of a complex formed between the antigen-binding fragment (Fab) of a neutralizing antibody and the membrane-distal domain ((HA top9) of a HA subunit prepared from HA in… CONTINUE READING
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