Structure of hypothalamic coronaro-constrictory peptide factors

  title={Structure of hypothalamic coronaro-constrictory peptide factors},
  author={Nina Barkhudaryan and Walter Oberthuer and Friedrich Lottspeich and Armen Anushavan Galoyan},
  journal={Neurochemical Research},
The following peptide structure in 3 of 5 coronaro-constrictory peptide factors isolated from bovine hypothalamus was determined by amino acid analysis and Edman degradation: 1) (P1)-Val-Val-Tyr-Pro-Trp; 2) (P2)-Val-Val-Tyr-Pro-Trp-Thr; 3) (P3)-Leu-Val-Val-Tyr-Pro-Trp-Thr. A computer search for these amino acid sequences revealed that these peptides represent fragments 33-37; 33-38; 32-38 of the β-chain of bovine hemoglobin. Solid phase peptide synthesis of 2 peptides (P2 and P3) was carried… CONTINUE READING