Structure of human dCK suggests strategies to improve anticancer and antiviral therapy

  title={Structure of human dCK suggests strategies to improve anticancer and antiviral therapy},
  author={Elisabetta Sabini and Stephan Ort and Christian Monnerjahn and M. HadeJ M. Konrad and Arnon Lavie},
  journal={Nature Structural Biology},
Human deoxycytidine kinase (dCK) phosphorylates the natural deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) and is an essential enzyme for the phosphorylation of numerous nucleoside analog prodrugs routinely used in cancer and antiviral chemotherapy. For many of these compounds, the phosphorylation step catalyzed by dCK is the rate-limiting step in their overall activation pathway. To determine the factors that limit the phosphorylation efficiency of the… CONTINUE READING
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Down - regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance

  • E. Mansson
  • Biochem . Pharmacol .
  • 2003

Phase II study of troxacitabine ( BCH - 4556 ) in patients with advanced and / or metastatic renal cell carcinoma : a trial of the National Cancer Institute of Canada - Clinical Trials Group

  • C. A. Townsley
  • J . Clin . Oncol .
  • 2003

Structural basis for substrate specificities of cellular deoxyri - bonucleoside kinases

  • K. Johansson
  • Nat . Struct . Biol .
  • 2001

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