Structure of human dCK suggests strategies to improve anticancer and antiviral therapy

@article{Sabini2003StructureOH,
  title={Structure of human dCK suggests strategies to improve anticancer and antiviral therapy},
  author={Elisabetta Sabini and Stephan Ort and Christian Monnerjahn and Manfred Konrad and Arnon Lavie},
  journal={Nature Structural Biology},
  year={2003},
  volume={10},
  pages={513-519}
}
Human deoxycytidine kinase (dCK) phosphorylates the natural deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) and is an essential enzyme for the phosphorylation of numerous nucleoside analog prodrugs routinely used in cancer and antiviral chemotherapy. For many of these compounds, the phosphorylation step catalyzed by dCK is the rate-limiting step in their overall activation pathway. To determine the factors that limit the phosphorylation efficiency of the… 
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A thorough and detailed knowledge of the molecular basis for substrate specificity will be a valuable tool for design and development of new and more efficient nucleoside analogs for cancer chemotherapy and viral diseases.
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