Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.

@article{Fusetti2002StructureOH,
  title={Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.},
  author={Fabrizia Fusetti and Holger von Moeller and Douglas E. Houston and Henriette J Rozeboom and Bauke W Dijkstra and Rolf G. Boot and Johannes M F G Aerts and Daan M F van Aalten},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 28},
  pages={
          25537-44
        }
}
Chitin hydrolases have been identified in a variety of organisms ranging from bacteria to eukaryotes. They have been proposed to be possible targets for the design of novel chemotherapeutics against human pathogens such as fungi and protozoan parasites as mammals were not thought to possess chitin-processing enzymes. Recently, a human chitotriosidase was described as a marker for Gaucher disease with plasma levels of the enzyme elevated up to 2 orders of magnitude. The chitotriosidase was shown… CONTINUE READING

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Glucosylceramide Lipidoses: Gaucher’s Disease, (Scriver

  • J. A. Barranger, E. I. Ginns
  • 1988
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