Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.

  title={Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.},
  author={Leslie L Lovelace and Christopher L. Cooper and James M. Sodetz and Lukasz Lebioda},
  journal={The Journal of biological chemistry},
  volume={286 20},
C8 is one of five complement proteins that assemble on bacterial membranes to form the lethal pore-like "membrane attack complex" (MAC) of complement. The MAC consists of one C5b, C6, C7, and C8 and 12-18 molecules of C9. C8 is composed of three genetically distinct subunits, C8α, C8β, and C8γ. The C6, C7, C8α, C8β, and C9 proteins are homologous and together comprise the MAC family of proteins. All contain N- and C-terminal modules and a central 40-kDa membrane attack complex perforin (MACPF… CONTINUE READING

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