Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.

@article{Lovelace2011StructureOH,
  title={Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.},
  author={Leslie L Lovelace and Christopher L. Cooper and James M. Sodetz and Lukasz Lebioda},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 20},
  pages={17585-92}
}
C8 is one of five complement proteins that assemble on bacterial membranes to form the lethal pore-like "membrane attack complex" (MAC) of complement. The MAC consists of one C5b, C6, C7, and C8 and 12-18 molecules of C9. C8 is composed of three genetically distinct subunits, C8α, C8β, and C8γ. The C6, C7, C8α, C8β, and C9 proteins are homologous and together comprise the MAC family of proteins. All contain N- and C-terminal modules and a central 40-kDa membrane attack complex perforin (MACPF… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
32 Citations
5 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

References

Publications referenced by this paper.
Showing 1-5 of 5 references

Turbo Frodo. Silicon Graphics Geometry Silicon Graphics, Mountain View

  • A. Roussel, C. Cambillau
  • 1991
Highly Influential
5 Excerpts

Complement protein C8

  • L. Lebioda, J. M. Sodetz
  • 2005

hp://w w w .jb.org/ D

  • P. Emsley, K. Cowtan
  • Acta. Crystallog., Sect D: Biol. Crystallogr. 60,
  • 2004
2 Excerpts

Proteins of the membrane attack complex. in The Human Complement System in Health and Disease (Volanakis

  • M. E. Plumb, M SodetzJ.
  • 1998

The evolution of biochemical syntheses – retrospect and prospect

  • N. H. Horowitz
  • Evolving Genes and Proteins,
  • 1965
1 Excerpt

Similar Papers

Loading similar papers…