Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.

@article{Jenni2007StructureOF,
  title={Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.},
  author={Simon Jenni and Marc Leibundgut and Daniel Boehringer and Christian Frick and Bohdan Mikol{\'a}sek and Nenad Ban},
  journal={Science},
  year={2007},
  volume={316 5822},
  pages={254-61}
}
We report crystal structures of the 2.6-megadalton alpha6beta6 heterododecameric fatty acid synthase from Thermomyces lanuginosus at 3.1 angstrom resolution. The alpha and beta polypeptide chains form the six catalytic domains required for fatty acid synthesis and numerous expansion segments responsible for extensive intersubunit connections. Detailed views of all active sites provide insights into substrate specificities and catalytic mechanisms and reveal their unique characteristics, which… CONTINUE READING
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  • A. Natl. Acad. Sci. U.S.
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  • 2006
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