Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin.

@article{FerrerOrta2010StructureOF,
  title={Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin.},
  author={Cristina Ferrer-Orta and Macarena Sierra and R. Garc{\'i}a Agudo and Ignacio de la Higuera and Armando Arias and Rosa P{\'e}rez-Luque and Cristina Escarm{\'i}s and Esteban Domingo and N{\'u}ria Verdaguer},
  journal={Journal of virology},
  year={2010},
  volume={84 12},
  pages={6188-99}
}
Passage of poliovirus (PV) or foot-and-mouth disease virus (FMDV) in the presence of ribavirin selected for viruses with decreased sensitivity to R, which included different mutations in their polymerase (3D): G64S located in the finger subdomain in the case of PV and M296I located within loop beta9-alpha11 at the active site in the case of FMDV. To investigate why disparate substitutions were selected in two closely related 3Ds, we constructed FMDVs with a 3D that included either G62S (the… CONTINUE READING
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Viral quasispecies: dynamics, interactions, and pathogenesis, p. 87–118

  • E. Domingo, C. Escarmís, +4 authors J. J. Holland
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