Structure of fischerin, a new toxic metabolite from an ascomycete, Neosartorya fischeri var. fischeri.

  title={Structure of fischerin, a new toxic metabolite from an ascomycete, Neosartorya fischeri var. fischeri.},
  author={Haruhiro Fujimoto and Mitsumasa Ikeda and K. Yamamoto and Mami Yamazaki},
  journal={Journal of natural products},
  volume={56 8},
A new toxic metabolite named fischerin [1] from an Ascomycete. Neosartorya fischeri var. fischeri, which caused lethal peritonitis in mice, was deduced to have a structure including a 1,4-dihydroxy-3,5-disubstituted-2(1H)-pyridone moiety by chemical and spectral data. 

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Three new 4-hydroxy-2-pyridone alkaloids, arthpyrones A-C (1-3), were isolated from the sponge-derived fungus Arthrinium arundinis ZSDS1-F3 and a possible biosynthetic pathway for them was proposed.

Three New Prenylated Diketopiperazines from Neosartorya fischeri

Three new prenylated 2,5-diketopiperazines, namely neofipiperazines A–C (1–3, resp.), were isolated from the culture of Neosartorya fischeri CGMCC 3.5378, together with six known ones. The structures

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4-Hydroxy-2-pyridone alkaloids: structures and synthetic approaches.

A summary of the so far known structures of the 4-Hydroxy-2-pyridone alkaloids, overview the different activities of the compounds and disclose the synthetic attempts since 1982 are given.

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During the search for the hemorrhagic factors from the Fusarium species, several toxins other than trichothecenes were isolated, and apicidin showed in vivo antitumor activity against P388 murine leukemia cell implanted mice with the effective dosages of 30-100 mg/kg by intraperitoneal administration.