Structure of eukaryotic RNA polymerases.

  title={Structure of eukaryotic RNA polymerases.},
  author={Patrick Cramer and K-J Armache and Sonja Baumli and Steven Benkert and Florian Brueckner and Claudia Buchen and Gerke E. Damsma and Stefan Dengl and Sebastian R. Geiger and Anna J Jasiak and Anass Jawhari and Stefan Jennebach and Tomislav Kamenski and Hubert Kettenberger and C-D Kuhn and Elisabeth Lehmann and Kristin Leike and Jasmin F. Sydow and Alessandro Vannini},
  journal={Annual review of biophysics},
The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a catalog of available structural information for these three enzymes. Most structural data have been accumulated for Pol II and its functional complexes. These studies have provided insights into many aspects of the transcription mechanism, including initiation at promoter DNA, elongation of the mRNA chain… CONTINUE READING
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