Structure of complement receptor 2 in complex with its C3d ligand.

@article{Szakonyi2001StructureOC,
  title={Structure of complement receptor 2 in complex with its C3d ligand.},
  author={Gerda Szakonyi and Joel M Guthridge and Dawei Li and Kendra Young and Vernon Michael Holers and Xiaojiang S. Chen},
  journal={Science},
  year={2001},
  volume={292 5522},
  pages={
          1725-8
        }
}
Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a… CONTINUE READING
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