Structure of class B GPCR corticotropin-releasing factor receptor 1

  title={Structure of class B GPCR corticotropin-releasing factor receptor 1},
  author={Kaspar Hollenstein and James Kean and Andrea Bortolato and Robert K. Y. Cheng and Andrew S. Dor{\'e} and Ali Jazayeri and R. M. Cooke and Malcolm Weir and Fiona H Marshall},
Structural analysis of class B G-protein-coupled receptors (GPCRs), cell-surface proteins that respond to peptide hormones, has been restricted to the amino-terminal extracellular domain, thus providing little understanding of the membrane-spanning signal transduction domain. The corticotropin-releasing factor receptor type 1 is a class B receptor which mediates the response to stress and has been considered a drug target for depression and anxiety. Here we report the crystal structure of the… CONTINUE READING
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