Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes.

@article{Moustakas2000StructureOC,
  title={Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes.},
  author={Antonis K. Moustakas and Yvonne van de Wal and John G. Routsias and Yvonne M. C. Kooy and Peter A. van Veelen and Jan Woulter Drijfhout and Frits Koning and George K. Papadopoulos},
  journal={International immunology},
  year={2000},
  volume={12 8},
  pages={1157-66}
}
The association of celiac disease (CD) with HLA-DQ2 and HLA-DQ8 is indicative of preferential mucosal T cell recognition of gluten fragments bound to either DQ allele. We have recently identified two gluten-derived, HLA-DQ8-restricted T cell stimulatory peptides, one each from gliadin and glutenin, recognized by specific T cell clones derived from the small intestine of CD patients. We have now performed molecular modeling and examined the fine specificity of these peptides in complex with HLA… CONTINUE READING

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