Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA

@article{Mckay1981StructureOC,
  title={Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA},
  author={David B. Mckay and Thomas A. Steitz},
  journal={Nature},
  year={1981},
  volume={290},
  pages={744-749}
}
The 2.9 Å resolution crystal structure of Escherichia coli catabolite gene activator protein (CAP) completed with cyclic AMP reveals two distinct structural domains separated by a cleft. The smaller carboxy-terminal domain is presumed to bind DNA while the amino-terminal domain is seen to bind cyclic AMP. Model building studies suggest that CAP binds to left-handed B-type DNA, contacting its major groove via two a-helices. It is possible that the CAP conversion of right- to left-handed DNA in a… 
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