Structure of cardiac gap junction intercellular channels.

  title={Structure of cardiac gap junction intercellular channels.},
  author={Mark Yeager},
  journal={Journal of structural biology},
  volume={121 2},
  • Mark Yeager
  • Published 1998 in Journal of structural biology
Gap junction proteins, termed connexins, constitute a multigene family of polytopic membrane channel proteins that have four hydrophobic transmembrane domains with the N- and C-termini located on the cytoplasmic membrane face. The principal gap junction protein in the heart, alpha 1 connexin (also designated Cx43), mediates action potential propagation between cells in order to synchronize cardiac contraction. alpha 1 connexin channels are concentrated in gap junction plaques located in the… CONTINUE READING