Structure of beta 2-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action.

Abstract

BACKGROUND beta-bungarotoxin is a heterodimeric neurotoxin consisting of a phospholipase subunit linked by a disulfide bond to a K+ channel binding subunit which is a member of the Kunitz protease inhibitor superfamily. Toxicity, characterized by blockage of neural transmission, is achieved by the lipolytic action of the phospholipase targeted to the… (More)

Topics

Cite this paper

@article{Kwong1995StructureOB, title={Structure of beta 2-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action.}, author={Peter D. Kwong and Nancy McDonald and Paul B. Sigler and Wayne A. Hendrickson}, journal={Structure}, year={1995}, volume={3 10}, pages={1109-19} }