Structure of astacin with a transition-state analogue inhibitor

  title={Structure of astacin with a transition-state analogue inhibitor},
  author={Frank Grams and Vincent Dive and Athanasios Yiotakis and Irene Yiallouros and Stamatia Vassiliou and Robert Zwilling and Wolfram Bode and Walter St{\"o}cker},
  journal={Nature Structural Biology},
The structure of the zinc peptidase astacin in complex with a phosphinic peptide suggests that a special role is played by the side chain of a zinc-bound tyrosine, which is shifted to form a hydrogen bond to the phosphinyl group—a mimic of the carboxyanion of the transition state. 

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