Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors.

@article{Wang2006StructureOA,
  title={Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors.},
  author={Xinquan Wang and Robert H Baloh and Jeffrey Milbrandt and K Christopher Garcia},
  journal={Structure},
  year={2006},
  volume={14 6},
  pages={
          1083-92
        }
}
Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET receptor. It represents a new receptor-ligand interaction mode for the… CONTINUE READING
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