Structure of an unusually stable RNA hairpin.

  title={Structure of an unusually stable RNA hairpin.},
  author={Graziano Varani and Chaejoon Cheong and Ignacio Tinoco},
  volume={30 13},
The structure of a very common RNA hairpin, 5'GGAC(UUCG)GUCC, has been determined in solution by NMR spectroscopy. The loop sequence, UUCG, occurs exceptionally often in ribosomal and other RNAs, and may serve as a nucleation site for RNA folding and as a protein recognition site. Reverse transcriptase cannot read through this loop, although it normally transcribes RNA secondary structure motifs. A hairpin with that loop displays unusually high thermodynamic stability; its stability decreases… CONTINUE READING