Structure of an unliganded simian immunodeficiency virus gp120 core

  title={Structure of an unliganded simian immunodeficiency virus gp120 core},
  author={Bing Chen and Erik M. Vogan and Haiyun Gong and John J. Skehel and Don C. Wiley and Stephen C Harrison},
Envelope glycoproteins of human and simian immunodeficiency virus (HIV and SIV) undergo a series of conformational changes when they interact with receptor (CD4) and co-receptor on the surface of a potential host cell, leading ultimately to fusion of viral and cellular membranes. Structures of fragments of gp120 and gp41 from the envelope protein are known, in conformations corresponding to their post-attachment and postfusion states, respectively. We report the crystal structure, at 4… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2003

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