Structure of an alpha-2,6-sialylated lipooligosaccharide from Neisseria meningitidis immunotype L1.

@article{Wakarchuk1998StructureOA,
  title={Structure of an alpha-2,6-sialylated lipooligosaccharide from Neisseria meningitidis immunotype L1.},
  author={Warren Wakarchuk and Michel Gilbert and Alejandro Mart{\'i}n and Yi Wu and Jessica Brisson and Pierre Thibault and James Carlton Richards},
  journal={European journal of biochemistry},
  year={1998},
  volume={254 3},
  pages={
          626-33
        }
}
The recent cloning of the lipooligosaccharide (LOS) a-2,3-sialyltransferase from Neisseria meningitidis immunotype L3 permitted us to examine other immunotypes for this structural gene. We identified the gene and measured the enzyme activity in the L1 immunotype strain which had previously been reported to lack sialic acid in its LOS because it contains a terminal alpha-linked galactose which was thought not to be an acceptor for the sialyltransferase. This finding prompted us to re-examine the… CONTINUE READING
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