Structure of an adenine˙cytosine base pair in DNA and its implications for mismatch repair

@article{Hunter1986StructureOA,
  title={Structure of an adenine˙cytosine base pair in DNA and its implications for mismatch repair},
  author={William N. Hunter and T. S. Brown and Naveen N. Anand and Olga Kennard},
  journal={Nature},
  year={1986},
  volume={320},
  pages={552-555}
}
Mutational pathways rely on introducing changes in the DNA double helix. This may be achieved by the incorporation of a noncomplementary base on replication or during genetic recombination1,2, leading to substitution mutation. In vivo studies3–7 have shown that most combinations of base-pair mismatches can be accommodated in the DNA double helix, albeit with varying efficiencies. Fidelity of replication requires the recognition and excision of mismatched bases by proofreading enzymes and post… 
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Of the DNA bases, the hydrogen bonding characteristics of guanine (G) are complementary only to those of cytidine (C) and, similarly, the hydrogen bonding characteristics of adenine (A) are
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TLDR
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Effects of base mismatches on the structure of the four-way DNA junction.
TLDR
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TLDR
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TLDR
High-resolution X-ray crystallographic analysis of a DNA polymerase that catalyzes replication in crystals observes that a C•A mismatch can mimic the shape of cognate base pairs at the site of incorporation, providing structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Methyl-directed Repair of Mismatched Small Heterologous Sequences in Cell Extracts from Escherichia coli *
TLDR
The results showed that the repair of small nucleotide heterologies in Escherichia coliextracts was very similar to base-base mismatch repair, being strand-specific and highly biased to the unmethylated strand.
Repair of a mismatch is influenced by the base composition of the surrounding nucleotide sequence.
TLDR
The results suggest that the transition mismatches are generally better repaired than the transversion mismatches and that, at least for the transversions mismatches studied, repair efficiency increases with increasing G:C content in the neighboring nucleotide sequence.
Recognition of nonhybridizing base pairs during nucleotide excision repair of DNA.
TLDR
The results indicate that the XPA-RPA complex may promote damage recognition by monitoring Watson-Crick base pair integrity, thereby recruiting the human NER system preferentially to sites where hybridization between complementary strands is weakened or entirely disrupted.
Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates.
We have refined a series of isomorphous crystal structures of the Escherichia coli DNA mismatch repair enzyme MutS in complex with G:T, A:A, C:A and G:G mismatches and also with a single unpaired
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