Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis.

Abstract

The Aspergillus fumigatus old yellow enzyme (OYE) EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine aldehyde and works in conjunction with festuclavine synthase at the branchpoint for ergot alkaloid pathways. The crystal structure of the FMN-loaded EasA was determined to 1.8 Å resolution. The active-site amino acids of OYE are conserved… (More)
DOI: 10.1107/S2053230X14018962

Topics

Cite this paper

@article{Chilton2014StructureOA, title={Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis.}, author={Annemarie S Chilton and Ashley L Ellis and Audrey L Lamb}, journal={Acta crystallographica. Section F, Structural biology communications}, year={2014}, volume={70 Pt 10}, pages={1328-32} }