Structure of an Ancient Respiratory System.

  title={Structure of an Ancient Respiratory System.},
  author={Hongjun Yu and Chang-Hao Wu and Gerrit J. Schut and Dominik K Haja and Gongpu Zhao and John W Peters and Michael W W Adams and Huilin Li},
  volume={173 7},
Hydrogen gas-evolving membrane-bound hydrogenase (MBH) and quinone-reducing complex I are homologous respiratory complexes with a common ancestor, but a structural basis for their evolutionary relationship is lacking. Here, we report the cryo-EM structure of a 14-subunit MBH from the hyperthermophile Pyrococcus furiosus. MBH contains a membrane-anchored hydrogenase module that is highly similar structurally to the quinone-binding Q-module of complex I while its membrane-embedded ion… CONTINUE READING
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