Structure of a voltage-dependent K+ channel beta subunit.

  title={Structure of a voltage-dependent K+ channel beta subunit.},
  author={Jacqueline M. Gulbis and Sabine Mann and Roderick MacKinnon},
  volume={97 7},
The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the beta subunit. One function of beta subunits is to modify K+ channel gating. We have determined the structure of the conserved core of mammalian beta subunits by X-ray crystallography at 2.8 A resolution. Like the integral membrane component of K+ channels, beta subunits form a four-fold symmetric structure. Each subunit is an oxidoreductase enzyme complete with a… CONTINUE READING