Structure of a ternary transcription activation complex.

  title={Structure of a ternary transcription activation complex.},
  author={Deepti Jain and Bryce E. Nickels and Li Sun and Ann Hochschild and Seth A Darst},
  journal={Molecular cell},
  volume={13 1},
The cI protein of bacteriophage lambda (lambdacI) activates transcription by binding a DNA operator just upstream of the promoter and interacting with the RNA polymerase sigma subunit domain 4 (sigma(4)). We determined the crystal structure of the lambdacI/sigma(4)/DNA ternary complex at 2.3 A resolution. There are no conformational changes in either protein, which interact through an extremely small interface involving at most 6 amino acid residues. The interactions of the two proteins… CONTINUE READING

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