Structure of a ribulose 5‐phosphate 3‐epimerase from Plasmodium falciparum

@article{Caruthers2006StructureOA,
  title={Structure of a ribulose 5‐phosphate 3‐epimerase from Plasmodium falciparum},
  author={Jonathan M. Caruthers and J{\"u}rgen Bosch and Frederick S. Buckner and Wesley C. Van Voorhis and Peter J. Myler and Elizabeth A. Worthey and Christopher Mehlin and Erica Boni and George T. DeTitta and Joseph R. Luft and Angela M. Lauricella and Oleksandr Kalyuzhniy and Lori Anderson and Frank Zucker and Michael Soltis and Wim G. J. Hol},
  journal={Proteins: Structure},
  year={2006},
  volume={62}
}
The crystal structure of Pfal009167AAA, a putative ribulose 5‐phosphate 3‐epimerase (PfalRPE) from Plasmodium falciparum, has been determined to 2 Å resolution. RPE represents an exciting potential drug target for developing antimalarials because it is involved in the shikimate and the pentose phosphate pathways. The structure is a classic TIM‐barrel fold. A coordinated Zn ion and a bound sulfate ion in the active site of the enzyme allow for a greater understanding of the mechanism of action… Expand
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