Structure of a rare non-standard sequence k-turn bound by L7Ae protein

  title={Structure of a rare non-standard sequence k-turn bound by L7Ae protein},
  author={Lin Huang and David M. J. Lilley},
  booktitle={Nucleic acids research},
Kt-23 from Thelohania solenopsae is a rare RNA kink turn (k-turn) where an adenine replaces the normal guanine at the 2n position. L7Ae is a member of a strongly conserved family of proteins that bind a range of k-turn structures in the ribosome, box C/D and H/ACA small nucleolar RNAs and U4 small nuclear RNA. We have solved the crystal structure of T. solenopsae Kt-23 RNA bound to Archeoglobus fulgidus L7Ae protein at a resolution of 2.95 Å. The protein binds in the major groove displayed on… CONTINUE READING

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