Structure of a new crystal form of human Hsp70 ATPase domain.

@article{Osipiuk1999StructureOA,
  title={Structure of a new crystal form of human Hsp70 ATPase domain.},
  author={Jerzy Osipiuk and Martin A. Walsh and Brian C. Freeman and Richard I. Morimoto and Andrzej Joachimiak},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={1999},
  volume={55 Pt 5},
  pages={1105-7}
}
Hsp70 proteins are highly conserved proteins induced by heat shock and other stress conditions. An ATP-binding domain of human Hsp70 protein has been crystallized in two major morphological forms at pH 7.0 in the presence of PEG 8000 and CaCl2. Both crystal forms belong to the orthorhombic space group P212121, but show no resemblance in unit-cell parameters. Analysis of the crystal structures for both forms shows a 1-2 A shift of one of the subdomains of the protein. This conformational change… CONTINUE READING

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