Structure of a nanobody-stabilized active state of the β2 adrenoceptor

@inproceedings{Rasmussen2011StructureOA,
  title={Structure of a nanobody-stabilized active state of the β2 adrenoceptor},
  author={S{\o}ren Feilberg Rasmussen and Hee-Jung Choi and Juan Jos{\'e} Fung and Els Pardon and Paola Casarosa and Pil Seok Chae and B Devree and Daniel M Rosenbaum and Foon Sun Thian and Tong Sun Kobilka and Andreas Schnapp and Ingo Konetzki and Roger K Sunahara and Samuel H. Gellman and Alexander Pautsch and Jan Steyaert and William I Weis and Brian K. Kobilka},
  booktitle={Nature},
  year={2011}
}
G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response to natural and synthetic ligands. Recent crystal structures provide insights into inactive states of several GPCRs. Efforts to obtain an agonist-bound active-state GPCR structure have proven difficult due to the inherent instability of this state in the absence of a G protein. We generated a camelid antibody fragment (nanobody) to the human β2 adrenergic receptor (β2AR) that exhibits G protein-like… CONTINUE READING
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