Structure of a human Tcf4-beta-catenin complex.

  title={Structure of a human Tcf4-beta-catenin complex.},
  author={Florence Poy and Maina Lepourcelet and Ramesh A. Shivdasani and Michael J. Eck},
  journal={Nature structural biology},
  volume={8 12},
The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins, and the Wnt signal transduction pathway, where it interacts with the Adenomatous polyposis coli (APC) protein and TCF/Lef family transcription factors. Mutations in APC or in beta-catenin are estimated to trigger formation of over 90% of all colon cancers. In colonic epithelia, these mutations produce elevated levels of Tcf4-beta-catenin, which stimulates a transcriptional response that… CONTINUE READING


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