Structure of a human Tcf4-beta-catenin complex.

@article{Poy2001StructureOA,
  title={Structure of a human Tcf4-beta-catenin complex.},
  author={Florence Poy and Maina Lepourcelet and Ramesh A. Shivdasani and Michael J. Eck},
  journal={Nature structural biology},
  year={2001},
  volume={8 12},
  pages={1053-7}
}
The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins, and the Wnt signal transduction pathway, where it interacts with the Adenomatous polyposis coli (APC) protein and TCF/Lef family transcription factors. Mutations in APC or in beta-catenin are estimated to trigger formation of over 90% of all colon cancers. In colonic epithelia, these mutations produce elevated levels of Tcf4-beta-catenin, which stimulates a transcriptional response that… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

The cadherin-catenin complex as a focal point of cell adhesion and signalling: new insights from three-dimensional structures.

BioEssays : news and reviews in molecular, cellular and developmental biology • 2004
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…