Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication.

Abstract

Herpesviruses require a nuclear egress complex (NEC) for efficient transit of nucleocapsids from the nucleus to the cytoplasm. The NEC orchestrates multiple steps during herpesvirus nuclear egress, including disruption of nuclear lamina and particle budding through the inner nuclear membrane. In the important human pathogen human cytomegalovirus (HCMV… (More)
DOI: 10.1073/pnas.1511140112

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