Structure of a heparin-dependent complex of Hedgehog and Ihog.

  title={Structure of a heparin-dependent complex of Hedgehog and Ihog.},
  author={Jason S McLellan and Shenqin Yao and Xiaoyan Zheng and Brian V. Geisbrecht and Rodolfo Ghirlando and Philip A Beachy and Daniel J. Leahy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 46},
Hedgehog (Hh) signaling molecules mediate key tissue-patterning events during animal development, and inappropriate activation of Hh signaling in adults has been associated with human cancers. Recently, a conserved family of type I integral membrane proteins required for normal response to the Hh signal was discovered. One member of this family, Ihog (interference hedgehog), functions upstream or at the level of Patched (Ptc), but how Ihog participates in Hh signaling remains unclear. Here, we… CONTINUE READING

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