Structure of a four-way bridged ParB-DNA complex provides insight into P1 segrosome assembly.

@article{Schumacher2007StructureOA,
  title={Structure of a four-way bridged ParB-DNA complex provides insight into P1 segrosome assembly.},
  author={Maria A. Schumacher and Andr{\'e} Martin Mansoor and Barbara E. Funnell},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 14},
  pages={10456-64}
}
The plasmid partition process is essential for plasmid propagation and is mediated by par systems, consisting of centromere-like sites and two proteins, ParA and ParB. In the first step of partition by the archetypical P1 system, ParB binds a complicated centromere-like site to form a large nucleoprotein segrosome. ParB is a dimeric DNA-binding protein that can bridge between both A-boxes and B-boxes located on the centromere. Its helix-turn-helix domains bind A-boxes and the dimer domain binds… CONTINUE READING

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