Structure of a eukaryotic decoding region A-site RNA.

@article{Lynch2001StructureOA,
  title={Structure of a eukaryotic decoding region A-site RNA.},
  author={Stephen R. Lynch and Joseph D. Puglisi},
  journal={Journal of molecular biology},
  year={2001},
  volume={306 5},
  pages={1023-35}
}
The aminoglycoside antibiotics target a region of highly conserved nucleotides in the aminoacyl-tRNA site (A site) of 16 S RNA on the 30 S subunit. The structures of a prokaryotic decoding region A-site oligonucleotide free in solution and bound to the aminoglycosides paromomycin and gentamicin C1A have been determined. Here, the structure of a eukaryotic decoding region A-site oligonucleotide has been determined using homonuclear and heteronuclear NMR spectroscopy, and compared to the unbound… CONTINUE READING