Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

@inproceedings{Goult2010StructureOA,
  title={Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation},
  author={Benjamin T Goult and Mohamed Bouaouina and Paul Elliott and Neil Bate and Bipin Patel and Alexandre R Gingras and J. G{\"u}nter Grossmann and Gordon C. K. Roberts and David A Calderwood and David R. Critchley and Igor L. Barsukov},
  booktitle={The EMBO journal},
  year={2010}
}
Talin is a 270-kDa protein that activates integrins and couples them to cytoskeletal actin. Talin contains an N-terminal FERM domain comprised of F1, F2 and F3 domains, but it is atypical in that F1 contains a large insert and is preceded by an extra domain F0. Although F3 contains the binding site for beta-integrin tails, F0 and F1 are also required for activation of beta1-integrins. Here, we report the solution structures of F0, F1 and of the F0F1 double domain. Both F0 and F1 have ubiquitin… CONTINUE READING

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