Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 Å resolution.


In the search of molecules that could recognize sizeable areas of protein surfaces, a series of ten helical aromatic oligoamide foldamers was synthesized on solid phase. The foldamers comprise three to five monomers carrying various proteinogenic side chains, and exist as racemic mixtures of interconverting right-handed and left-handed helices… (More)
DOI: 10.1002/anie.201309160


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