Structure of a cannabinoid receptor and functional expression of the cloned cDNA

@article{Matsuda1990StructureOA,
  title={Structure of a cannabinoid receptor and functional expression of the cloned cDNA},
  author={L. Matsuda and S. Lolait and M. Brownstein and Alice C. Young and T. Bonner},
  journal={Nature},
  year={1990},
  volume={346},
  pages={561-564}
}
MARIJUANA and many of its constituent cannabinoids influence the central nervous system (CNS) in a complex and dose-dependent manner1,2. Although CNS depression and analgesia are well documented effects of the cannabinoids, the mechanisms responsible for these and other cannabinoid-induced effects are not so far known3. The hydrophobic nature of these substances has suggested that cannabinoids resemble anaesthetic agents in their action, that is, they nonspecifically disrupt cellular membranes… Expand
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