Structure of a Voltage-Dependent K+ Channel β Subunit

  title={Structure of a Voltage-Dependent K+ Channel β Subunit},
  author={Jacqueline M. Gulbis and Sabine Mann and Roderick MacKinnon},
in membrane voltage, this kind of ion channel undergoes a conformational change that opens the ion conduction pathway. The Shaker K ϩ channel from Drosophila mela-shaking phenotype of flies in which the channel gene is mutated. It is interesting that two of the early described shaking phenotypes of Drosophila, the hyperkinetic mutants , result from mutations in a K ϩ channel ␤ subunit Summary gene (Chouinard et al., 1995). In these mutant flies, the ether-induced leg shaking is distinguishable… CONTINUE READING


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