Structure of a VEGF–VEGF receptor complex determined by electron microscopy

@article{Ruch2007StructureOA,
  title={Structure of a VEGF–VEGF receptor complex determined by electron microscopy},
  author={C. Ruch and Georgios Skiniotis and Michel O. Steinmetz and Thomas Walz and Kurt Ballmer-Hofer},
  journal={Nature Structural &Molecular Biology},
  year={2007},
  volume={14},
  pages={249-250}
}
Receptor tyrosine kinases are activated upon ligand-induced dimerization. Here we show that the monomeric extracellular domain of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) has a flexible structure. Binding of VEGF to membrane-distal immunoglobulin-like domains causes receptor dimerization and promotes further interaction between receptor monomers through the membrane-proximal immunoglobulin-like domain 7. By this mechanism, ligand-induced dimerization of VEGFR-2 can be… CONTINUE READING
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