Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition.

@article{Juillerat2011StructureOA,
  title={Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition.},
  author={Alexandre Marcel Juillerat and Anita Lewit-Bentley and Micheline Guillotte and St{\'e}phane Gangnard and Audrey Hessel and Bruno Baron and Ines Vigan-Womas and Patrick England and Odile Mercereau-Puijalon and Graham A Bentley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 13},
  pages={
          5243-8
        }
}
The human malaria parasite Plasmodium falciparum can cause infected red blood cells (iRBC) to form rosettes with uninfected RBC, a phenotype associated with severe malaria. Rosetting is mediated by a subset of the Plasmodium falciparum membrane protein 1 (PfEMP1) variant adhesins expressed on the infected host-cell surface. Heparin and other sulfated oligosaccharides, however, can disrupt rosettes, suggesting that therapeutic approaches to this form of severe malaria are feasible. We present a… CONTINUE READING

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SHOWING 1-10 OF 39 REFERENCES

Biochemical and biophysical characterisation of DBL1α1-varO, the rosetting domain of PfEMP1 from the VarO line of Plasmodium falciparum

  • A Juillerat
  • Mol Biochem Parasitol
  • 2010
Highly Influential
9 Excerpts

An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype

  • I Vigan-Womas
  • Infect Immun
  • 2008
Highly Influential
5 Excerpts

of the thrombospondin - 1 N - terminal domain and its complex with a synthetic pentameric heparin

  • I Vigan-Womas
  • 2011

High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children

  • OK Doumbo
  • Am J Trop Med Hyg 81:987–93
  • 2009

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